ANTITHROMBIN III LEVEL IN PATIENTS OF β-THALASSEMIA: A CROSS-SECTIONAL STUDY

  • Ammar Bin Saad Abbottabad International Medical College, Abbottabad, Pakistan
  • Javed Iqbal Khan Abbottabad International Medical College, Abbottabad, Pakistan
  • Tahir Angez Khan Abbottabad International Medical College, Abbottabad, Pakistan
  • Muhammad Basharat Khan Abbottabad International Medical College, Abbottabad, Pakistan
  • Nadia Altaf North West School of Medicine, Peshawar, Pakistan
Keywords: Antithrombin, Thalassemia, Antithrombin III, Splenectomy, Splenectomized, Normality

Abstract

Background: Thalassemia is a genetic disorder associated with reduced production rate of either a single or more globin chains in the haemoglobin. Thalassemia is divided into two main types, alpha (α) thalassemia and beta (β) thalassemia. The aim of this study was to determine antithrombin III level in diagnosed patients of beta thalassemia major. Methods: This cross-sectional study was conducted at Sheikh Zayed Hospital Lahore from Jan 2014 to Jan 2015. The sample size was 100 including 50 healthy controls and 50 patients with β thalassemia major. Antithrombin III assay was done with Chromogenic determination of Antithrombin (AT) on an auto analyzer. Results: Mean age splenectomized group was 9.1±2.2 years and that for non-splenectomized and control group was 6.5±2.9. The mean antithrombin III level for the splenectomized group was 66.0±8.9% and that for non-splenectomized and control group was 78.6±9.6 and 91.9±4.7 respectively. The overall mean antithrombin III level for cases was 75.8±10.7. The differences for antithrombin III level were significant (p<0.001). The splenectomized group also had significantly lower antithrombin III level as compared to the non-splenectomized group (p=0.001). Conclusion: Antithrombin III level is significantly affected in thalassemia. A considerable difference was observed in antithrombin III levels of splenectomized and non-splenectomized patients.

Keywords: Antithrombin, Thalassemia, Splenectomized, Normality

Pak J Physiol 2018;14(4):40–3

Author Biographies

Ammar Bin Saad, Abbottabad International Medical College, Abbottabad, Pakistan

Assistant Professor,

Department of Pathology,

Abbottabad International Medical College,

Abbottabad, Pakistan.

Javed Iqbal Khan, Abbottabad International Medical College, Abbottabad, Pakistan

Assistant Professor,

Department of Surgery,

Abbottabad International Medical College,

Abbottabad, Pakistan.

Tahir Angez Khan, Abbottabad International Medical College, Abbottabad, Pakistan

Assistant Professor,

Department of Medicine,

Abbottabad International Medical College,

Abbottabad, Pakistan.

Muhammad Basharat Khan, Abbottabad International Medical College, Abbottabad, Pakistan

Department of Pathology,

Abbottabad International Medical College,

Abbottabad, Pakistan.

Nadia Altaf, North West School of Medicine, Peshawar, Pakistan

North West School of Medicine,

Peshawar, Pakistan.

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Published
2018-12-31
How to Cite
1.
Saad A, Khan J, Khan T, Khan M, Altaf N. ANTITHROMBIN III LEVEL IN PATIENTS OF β-THALASSEMIA: A CROSS-SECTIONAL STUDY. PJP [Internet]. 31Dec.2018 [cited 16Feb.2019];14(4):40-3. Available from: http://www.pjp.pps.org.pk/index.php/PJP/article/view/1026