Association of high sensitivity C reactive protein, glycated hemoglobin, body mass index and blood pressure in patients with type two diabetes mellitus.

Abstract

Background: Diabetes is characterized by hyperglycaemia resulting from defective secretion, defective action, or both of insulin. The aim of this study was to determine the high sensitivity C-Reactive Protein (hs-CRP) levels in type 2 diabetics and correlate hs-CRP levels with glycaemic control (Glycated Haemoglobin HbA1c levels), body mass index (BMI) and blood pressure. Methodology: It was a cross-sectional study carried out at Endocrinology Unit of Hayatabad Medical complex (HMC) and samples were analyzed in the laboratory of Rehman Medical Institute, Peshawar. A total of 125 known diabetic patients were recruited by non-probability convenience sampling. HbA1c, and hs-CRP were measured through immunoassay method besides Fasting Blood Glucose, Blood Pressure, Height and Weight. Results: Out of 125 patients, 68% were females and 32% were males, 16% had normal BMI, 48% were overweight and 36% were obese. In the male patients, 4% had good, and 28% had poor glycaemic control. In females, 8.8% had good glycaemic control and 59.2% had poor glycaemic control. There was significant small positive correlation of HbA1c and hs-CRP (r=0.207, p=0.020), significant weak positive correlation of hs-CRP and BMI (r=0.299, p=0.001), and no correlation of hs-CRP and systolic blood pressure in the data (r=0.059, p=0.555). Conclusion: There is a positive association of hs-CRP with HbA1c and BMI. If better glycaemic control is maintained, chances of getting cardiovascular diseases are reduced.