CORRELATION OF TUMOUR NECROSIS FACTOR-α WITH OBESITY INDUCED INSULIN RESISTANCE IN TYPE 2 DIABETES MELLITUS
Background: Obesity is a major cause of many metabolic disorders characterized by chronic inflammation that is linked with T2DM and insulin resistance. Tumour Necrosis Factor Alpha (TNF-α) is remarkably higher in obese people. The aim of this study was to determine the levels of TNF-α and its correlation with insulin resistance and body mass index in type 2 diabetic patients. Methods: This study was conducted at Diabetic Clinic of Mayo Hospital, Lahore. TNF-α levels were determined and correlated with insulin resistance and body mass index in 90 obese type 2 diabetics. TNF-α and serum insulin were determined using ELISA. Insulin resistance was calculated by HOMA-IR. Pearson correlation test was used to correlate TNF-α with Insulin Resistance and body mass index, and p≤0.05 was considered statistically significant. Results: There was a strong positive correlation of fasting insulin and HOMA-IR with TNF-α (r=0.986, p<0.001). There was also strong positive correlation of TNF-α with BMI. Conclusion: Increased inflammation in obese diabetics explains the role of TNF-α in insulin resistance caused by obesity. Weight reduction in obese individuals will help in reducing TNF-α levels and to improve insulin sensitivity in T2DM.
Pak J Physiol 2018;14(2):18–20
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