MODULATION OF VISFATIN LEVELS BY THIAZOLIDINEDIONES IN INSULIN RESISTANT SPRAGUE DAWLEY RATS
Background: Insulin resistance is manifested by decreased effect of fixed quantity of insulin on glucose metabolism leading to type 2 diabetes mellitus. Visceral obesity has a positive correlation with insulin resistance but its mechanism is not fully defined. Insulin resistance may be the consequence of adipocytokines including visfatin and resistin. This study was designed to see the effect of thiazolidinediones on visfatin levels in insulin resistant rats. Methods: Ninety Sprague Dawley rats were divided into 3 groups of 30 each. Group I served as control. Rats in Group II and III were made insulin resistant diabetics with high sucrose diet. Group III was treated with thiazolidinediones after development of diabetes. Plasma glucose, serum triglycerides, HDL, TG:HDL ratio and serum visfatin levels were analysed. Results: Body weight and plasma glucose, visfatin levels and TG:HDL ratio were significantly increased (p<0.05) in group II and group III at the end of 4th week. Treatment of group III with thiazolidinediones led to improvement in insulin resistance with increase in serum visfatin levels (p<0.05). Conclusion: Thiazolidinediones augment sensitivity of insulin to restore normoglycaemia by increasing serum visfatin level.
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