EFFECT OF ERADICATION OF HELICOBACTER PYLORI INFECTION ON THE PLATELET COUNTS IN PATIENTS PRESENTING WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA

Authors

  • Lubna Humayun Department of Pathology. University College of Medicine, University of Lahore. Lahore. Pakistan.
  • Muhammad Aafaak Agha Department of Histopathology, Sheikh Zayed Postgraduate Medical Institute, Lahore, Pakistan.
  • Asma Rasheed Department of Pathology University College of Medicine and Dentistry, University of Lahore, Pakistan.
  • M Javed Asif Department of Pathology University College of Medicine and Dentistry, University of Lahore, Pakistan.
  • Mulazim Hussain Bukhari Department of Pathology University College of Medicine and Dentistry, University of Lahore, Pakistan.

Keywords:

Eradication therapy, H. pylori, Thrombocytopenic Purpura, Platelets, Thrombocytopenia

Abstract

Background: Idiopathic thrombocytopenic purpura (ITP) is a rare autoimmune disease characterized by the platelet destruction that is autoantibody mediated, and there is suboptimal platelet production in the absence of a known cause, this leads to decreased peripheral blood platelet counts or thrombocytopenia and Helicobacter pylori has direct association with ITP. The aim of this study was to see the platelet recovery in patients of ITP after the H. pylori infection eradication. Methods: This was a case control study and 120 ITP patients who tested positive for H. pylori (divided into age and sex matched treatment and the control groups) were enrolled from the outdoor patients (OPD) of Sheikh Zayed Medical Complex. Stool antigen (HpSA) enzyme immunoassay method (EIA) method was used for H. pylori detection. Results: The response of the platelet count in the treatment group was a ‘complete response’ in 35 (60.3%) patients, a partial response in 16 (27.6%) patients and no response was found in 7 (12.1%) cases. However, no remarkable change was seen in the platelet counts of the patients in the control group. Conclusion: Complete eradication of H. pylori helps in the recovery of H. pylori induced platelet reduction and detection and eradication of H. pylori infection should be considered in the work-up of patients with ITP.

Keywords: Eradication therapy, H. pylori, Idiopathic Thrombocytopenic Purpura, Platelet counts Thrombocytopenia

Pak J Physiol 2017;13(2):41–3

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Author Biography

Lubna Humayun, Department of Pathology. University College of Medicine, University of Lahore. Lahore. Pakistan.

Assistant Professor, Department of Pathology. University College of Medicine, University of Lahore. Lahore. Pakistan.

References

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Pak J Physiol 2017;13(2)

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Published

30-06-2017

How to Cite

1.
Humayun L, Agha MA, Rasheed A, Asif MJ, Bukhari MH. EFFECT OF ERADICATION OF HELICOBACTER PYLORI INFECTION ON THE PLATELET COUNTS IN PATIENTS PRESENTING WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA. Pak J Phsyiol [Internet]. 2017 Jun. 30 [cited 2024 Apr. 24];13(2):41-5. Available from: https://www.pjp.pps.org.pk/index.php/PJP/article/view/51

Issue

Vol. 13 No. 2 (2017): Pakistan Journal of Physiology

Section

Original Article

License

Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, cited and quoted with full reference of, and acknowledgement to the PJP.