HYPERLIPIDEMIAS, DIABETES AND DEPRESSION

Authors

  • Saara Ahmad Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan.
  • Rehana Rehman Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan
  • Saida Haider Department of Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan
  • Zehra Batool Department of Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan
  • Fatima Ahmed Department of Ophthalmology, Liaquat National Hospital and Medical College, Karachi, Pakistan
  • Saad Bilal Ahmed Department of Geriatrics, Monash University, Melbourne, Australia

Keywords:

Diabetes mellitus, hyperlipidemias, depression, serotonin, tryptophan

Abstract

Background: Factors causing increased cholesterol levels in the body may include inactivity, obesity, genetic factors and an unhealthy diet. The high colesterol levels or hyperlipidemias may contribute to high concentrations of its precursor triglycerides and low density lipoproteins in plasma of the individuals. High triglyceride levels signal insulin resistance. This study was designed to determine an association of hyperlipidemia and diabetes mellitus with depression. Method: This case-control study involved 30 patients diagnosed with type 2 Diabetes Mellitus (DM) and hyperlipidemia (HL), and 30 non-diabetic healthy individuals having normal glucose tolerance test and no other co-morbidity. All subjects were of 30–50 years age. Blood samples from all participants were collected for determination of the HbA1C and lipid profiles. PQ9 score questionnaire for depression was asked from all subjects. Results: Patients suffering with hyperlipidemias and diabetes mellitus had higher incidence of depression compared to healthy subjects (p<0.05). Conclusion: Depression was more prevalent in hyperlipidemic and diabetic patients.

Pak J Physiol 2017;13(3):8–11

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Author Biography

Saara Ahmad, Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan.

Dr. Saara Ahmad,

Department of Biological and Biomedical Sciences,

The Aga Khan University, Karachi, Pakistan.

Cell: +92-334-3448258

Email: saara_ahmad@hotmail.com

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Pak J Physiol 2017;13(3)

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Published

30-09-2017

How to Cite

1.
Ahmad S, Rehman R, Haider S, Batool Z, Ahmed F, Ahmed SB. HYPERLIPIDEMIAS, DIABETES AND DEPRESSION. Pak J Phsyiol [Internet]. 2017 Sep. 30 [cited 2024 Apr. 19];13(3):8-11. Available from: https://www.pjp.pps.org.pk/index.php/PJP/article/view/71

Issue

Vol. 13 No. 3 (2017): Pakistan Journal of Physiology

Section

Original Article

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Pakistan Journal of Physiology, Pak J Physiol, PJP is FREE for research and academic purposes. It can be freely downloaded and stored, printed, presented, cited and quoted with full reference of, and acknowledgement to the PJP.