COMPARISON OF INTRAVENOUS DIAZEPAM AND INTRAVENOUS MIDAZOLAM FOR TREATMENT OF RECURRENT FEBRILE SEIZURES

Authors

  • Waseem Pasha Department of Paediatrics, CMH Kharian Medical College, Kharian, Pakistan
  • Awais Amjad Department of Physiology, CMH Kharian Medical College, Kharian, Pakistan
  • Imran Ahmed Department of Medicine , CMH Kharian Medical College, Kharian, Pakistan
  • Usman Nawaz Department of Pharmacology, CMH Kharian Medical College, Kharian, Pakistan
  • Usman Sajid Department of Medicine, CMH Kharian Medical College, Kharian, Pakistan
  • Usman Ali Department of Physiology, CMH Kharian Medical College, Kharian, Pakistan

Keywords:

midazolam, diazepam, febrile seizures, efficacy

Abstract

Background: Recurrent febrile seizures are seizures in children less than 5 years of age which reoccur within 24 hours.  Benzodiazepines such as midazolam and diazepam are used to stop and decrease the recurrent rate of febrile seizures. The objective of study was to compare the efficacy of intravenous midazolam with intravenous diazepam for treatment of recurrent febrile seizures in paediatric patients. Methods: This observational cross-sectional study observed 60 children aged 6 to 59 months with recurrent febrile seizures who presented at paediatric clinic in Combined Military Hospital Kharian and THQ Hospital, Kharian from Sep to Nov 2023. The response time was noted for children who received intravenous midazolam 0.2 mg/Kg only and IV diazepam 0.2 mg/Kg only. The children were randomly allocated into group A (midazolam group) and Group B (diazepam group.) Study was done after taking informed consent from the parents. Both drugs were given during the fits. Results: The time interval from drug administration to cessation of febrile seizures was 2.50±0.94 minutes in the midazolam group and 2.4±1.12 minutes in the diazepam group. There was no significant difference between the two groups (p=0.567). Minor dizziness and sedation were the only main effects reported. Conclusion: Both diazepam and midazolam have same efficacy in the treatment of recurrent febrile seizures.

Pak J Physiol 2024;20(1):12?4

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Published

31-03-2024

How to Cite

1.
Pasha W, Amjad A, Ahmed I, Nawaz U, Sajid MU, Ali MU. COMPARISON OF INTRAVENOUS DIAZEPAM AND INTRAVENOUS MIDAZOLAM FOR TREATMENT OF RECURRENT FEBRILE SEIZURES . Pak J Phsyiol [Internet]. 2024 Mar. 31 [cited 2024 Jun. 17];20(1):12-4. Available from: https://www.pjp.pps.org.pk/index.php/PJP/article/view/1597