EFFECTS OF L-CARNITINE THERAPY ON FAT AND GLUCOSE METABOLISM AMONG MELDONIUM INDUCED CARNITINE DEPLETION IN ALBINO WISTAR RATS

Authors

  • Sumayya Qazi Department of Biochemistry, Isra University, Hyderabad, Pakistan.
  • Mumtaz Ali Qureshi Department of Biochemistry, Isra University, Hyderabad, Pakistan.
  • Abroo Fatima Qazi Department of Physiology, Isra University, Hyderabad, Pakistan.
  • Amin Fahim Peoples University of Medical and Health Sciences For Women, Nawabshah, Pakistan
  • Ghulam Shah Nizamani Department of Pathology, Isra University, Hyderabad, Pakistan
  • Bakhtawar Qureshi Department of Community Medicine, Isra University, Hyderabad, Pakistan

Keywords:

Blood glucose, Carnitine, Cholesterol, Lipoproteins, HDL, LDL

Abstract

Background: L-carnitine therapy has a potential role in lipid metabolism and glucose homeostasis. Despite its promising effects, further investigation is warranted. This study aimed to determine the impact of L-carnitine therapy of low and high doses on fat and glucose metabolism of albino Wistar rats after Meldonium induced carnitine depletion. Methods: A total number of 48 albino Wistar rats were recruited and divided into four groups 12 rats in each group. The bedding material was changed every second day and all animals were given Kaytee Supreme Fortified Daily Diet rat food and clean distal water ad libitum at room temperature. The experiment was commenced after 10 days of acclimatization. Results: Both high (300 mg/Kg) and low-dose (500 mg/Kg) L-carnitine significantly improved (p<0.05) blood glucose levels, TC, LDL, and HDL after four weeks of L-carnitine therapy. However, high-dose therapy showed significantly higher HDL improvements and decreased TC and LDL levels than low-dose therapy (p<0.05) among Meldonium carnitine-depleted rats. Conclusion: L-carnitine high dose therapy (500 mg/Kg of body weight) had a more potent effect on lipid profile in comparison to low dose (300 mg/Kg of body weight).

Pak J Physiol 2024;20(1):26-9

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Published

31-03-2024

How to Cite

1.
Qazi S, Qureshi MA, Qazi AF, Fahim A, Nizamani GS, Qureshi B. EFFECTS OF L-CARNITINE THERAPY ON FAT AND GLUCOSE METABOLISM AMONG MELDONIUM INDUCED CARNITINE DEPLETION IN ALBINO WISTAR RATS: . Pak J Phsyiol [Internet]. 2024 Mar. 31 [cited 2024 Jun. 17];20(1):26-9. Available from: https://www.pjp.pps.org.pk/index.php/PJP/article/view/1610