• Fatima Zehra Department of Medical Education, Bahria University Health Sciences Campus, Karachi, Pakistan


Uric acid, Glycated hemoglobin, Diabetes mellitus, T2DM, HbA1C, Biomarker, Complications


Diabetes mellitus type 2 (T2DM) is a disease which imposes a great burden on the health resources of the emerging and developing world. It is a global pandemic which leads to chronic complications. Serum uric acid (SUA) is a biomarker that could be of value in detection of early complications and better prognosis in diabetic patients. SUA serves both as a causal factor and disease progression marker in DM, having a causal relationship with diabetic complications. This narrative review aims to determine the association between SUA and T2DM. Research articles from the year 2005 to 2023 were selected for this review. Literature search was conducted from PubMed and Google Scholar which resulted in short listing of 15 articles. It also reflects upon the diabetic complications associated with Hyperuricemia (HUA) and focuses on the health implications of HUA in T2DM patients. SUA and T2DM were negatively associated in 8 research studies and positively associated in 6 studies in which one revealed a partial association, one was prevalent in the female gender only, and one was negatively associated in uncontrolled DM. Another study was associated with both hypouricemia and HUA.

Pak J Physiol 2024;20(1):52-7


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How to Cite

Zehra F. ASSOCIATION OF SERUM URIC ACID WITH DIABETES MELLITUS TYPE-2: A NARRATIVE REVIEW. Pak J Phsyiol [Internet]. 2024 Mar. 31 [cited 2024 Jun. 17];20(1):52-7. Available from: