ALLEVIATION OF ARSENIC INDUCED THYROID DYSFUNCTION AND BODY WEIGHT ALTERATIONS BY CURCUMIN

Authors

  • Amaidah Mir CMH Kharian Medical College, Kharian, Pakistan
  • Urfa Zaryab Mir Department of Biochemistry, CMH Kharian Medical College, Kharian, Pakistan
  • Warda Hussain Department of Pathology, Nawaz Sharif Medical College, Gujrat, Pakistan
  • Hammad Ahmed Butt Department of Pharmacology, CMH Kharian Medical College, Khatian, Pakistan
  • Saqib Mansoor Department of Anatomy, Niazi Medical and Dental College, Sargodha, Pakistan
  • Maria Yasmeen Department of Anatomy, Watim Dental and Medical College, Rawat, Pakistan

DOI:

https://doi.org/10.69656/pjp.v20i3.1686

Keywords:

Arsenic, Curcumin, Triiodothyronine, tetraiodothyronine

Abstract

Background: Arsenic is notorious for being used in many homicidal cases. This study was designed to observe the toxic effects of low dose of arsenic on thyroid gland and body weight and its amelioration by curcumin. Method: Thirty healthy female Sprague Dawley rats (body weight ~230 g) were procured from The National Institute of Health Islamabad. After one week of acclimatization, animals were randomly divided into three groups (n=10 each), e.g., Control group (C), Experimental group-1 (E1) and Experimental group-2 (E2). The duration of the experiment was one month. Weight of the animals was checked before and at the end of experiment. All the animals were continued on standard diet and distilled water during experimental period. E1 was given 10 µg/10 mL of arsenic by oral gavage daily. E2 was given 10 µg/10 mL of arsenic along with Curcumin (50 mg/Kg body weight/day). At the end of experiment, the rats were euthanized to draw the blood and removal of thyroid gland. Serum Triiodothyronine, Tetraiodothyronine and Thyroid Stimulating Hormone were measured by ELISA. Histological changes were observed after haematoxylin and eosin staining. Statistical analysis was done on SPSS-22 and p?0.05 was considered significant. Results: The histological findings of thyroid gland, body weight and serum T3, T4 and TSH in E1 exhibited abnormal results. E2 group showed the protecting role of curcumin suggesting protective role of curcumin. Conclusion: Curcumin has protective effects against arsenic induced thyroid disruption and body weight alterations.

Pak J Physiol 2024;20(3):  DOI: https://doi.org/10.69656/pjp.v20i3.1686

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Author Biographies

Amaidah Mir, CMH Kharian Medical College, Kharian, Pakistan

Assistant Professor Anatomy, CMH Kharian Medical College, Kharian, Pakistan

Warda Hussain, Department of Pathology, Nawaz Sharif Medical College, Gujrat, Pakistan

Assistant professor of Pathology Nawaz sharif medical college, Gujrat

Hammad Ahmed Butt, Department of Pharmacology, CMH Kharian Medical College, Khatian, Pakistan

Assistant professor of Pharmacology, CMH Kharian Medical College Kharian

Saqib Mansoor, Department of Anatomy, Niazi Medical and Dental College, Sargodha, Pakistan

Assistant professor of Anatomy at Niazi Medical and Dental College Sargodha

Maria Yasmeen, Department of Anatomy, Watim Dental and Medical College, Rawat, Pakistan

Assistant professor of Anatomy Watim medical and dental college rawat

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Published

30-09-2024

How to Cite

1.
Mir A, Mir UZ, Hussain W, Butt HA, Mansoor S, Yasmeen M. ALLEVIATION OF ARSENIC INDUCED THYROID DYSFUNCTION AND BODY WEIGHT ALTERATIONS BY CURCUMIN. Pak J Phsyiol [Internet]. 2024 Sep. 30 [cited 2024 Dec. 4];20(3):40-3. Available from: https://www.pjp.pps.org.pk/index.php/PJP/article/view/1686