COMPARISON OF SERUM LIPID PARAMETERS IN NORMAL, DIABETIC AND TURMERIC TREATED DIABETIC RATS
DOI:
https://doi.org/10.69656/pjp.v21i4.1874Keywords:
Curcumin, Diabetes Mellitus, Lipid parametersAbstract
Background: Alteration in lipid profile is a common complication of diabetes leading to life threatening conditions. Aim of this study was to compare serum lipid profile parameters in control, diabetic and diabetic animals given turmeric powder and to determine the improvements in lipid profile in diabetic rats with the use of turmeric powder. Methods: In this experimental study, carried out at Postgraduate Medical Institute Lahore, 45 albino rats were randomly divided into three equal groups (normal control, diabetic and diabetic receiving turmeric therapy). Initially, Alloxan was administered to all the animals except normal control to produce diabetes. After confirmation of diabetes, one diabetic group was selected to be treated with turmeric powder dissolved in water in dosage of 250 mg/Kg body weight. Blood samples were obtained from rats after 12-hour fasting period at the start of experiment after confirmation of diabetes, week eight and week twelve. Results: When comparison was made, mean values of lipid profile parameters were significantly higher for diabetic control and diabetic animals receiving turmeric therapy as compared to normal control during week eight but the difference between both the diabetic groups was also significant. By the end of week twelve the difference between normal control and diabetic animals receiving turmeric therapy became non-significant with improvement in lipid profile parameters of diabetic rats receiving turmeric powder. Conclusion: Therapy with turmeric powder induces improvement in lipid profile of diabetic rats with dyslipidemia.
Pak J Physiol 2025;21(4):26–9, DOI: https://doi.org/10.69656/pjp.v21i4.1874
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