ANTIHYPERTENSIVE EFFECTS OF ETHANOLIC EXTRACT OF TRAPA NATANS SEEDS IN L-NAME-INDUCED HYPERTENSIVE RATS
DOI:
https://doi.org/10.69656/pjp.v22i1.1888Keywords:
Hypertension, Invasive blood pressure, L-NAME, Non-invasive blood pressure, Trapa natansAbstract
Background: There is need for safer and cost-effective therapeutic intervention for hypertension. Trapa natans exhibits antioxidant and anti-inflammatory activity. However, its efficacy as an antihypertensicve has not yet been established. This study aimed to examine the potential antihypertensive effect of ethanolic extract of Trapa natans seed in L-NG-Nitro Arginine Methyl Ester (L-NAME) induced hypertensive rats. Methods: This study used 30 rats which were divided into six groups of five rats each. The control group was given 5 mg/Kg normal saline. L-NAME and captopril (20 mg/Kg) were given to the second group. L-NAME and different doses of Trapa natans were given to 3rd, 4th, 5th and 6th groups. Non-invasive blood pressure was checked weekly. On the 29th day, the invasive blood pressure of the animals was checked. Results: The results showed that the non-invasive blood pressure altered substantially across the groups over time, especially the dose of 400 mg/Kg Trapa natans notably reduced the blood pressure. By the end of 28 days the invasive blood pressure also showed a noteworthy reduction in blood pressure for the dose of 400 mg/Kg Trapa natans. Conclusion: This study supports the beneficial ability of Trapa natans in lessening L-NAME induced hypertension. Its effects are likely to be caused by its phytochemical constituent, which demonstrates strong antioxidants and anti-inflammatory activities of Trapa natans.
Pak J Physiol 2026;22(1):9–11, DOI: https://doi.org/10.69656/pjp.v22i1.1888
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Copyright (c) 2026 Maria Liaqat, Khadija Mastoor, Muhammad Naveed Mushtaq, Huma Sohail, Salman Haider Shah Hashmi, Aqsa Arif
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